COVID-19 has caused massive disruption and destruction worldwide, with millions of deaths since 2019. Vaccination plays a vital role in ending COVID-19. The objective of the study was to assess
the acceptance of the COVID-19 vaccine and its determinants among the general population aged 18 years and above. A total of 506 participants were interviewed in the study. A quantitative questionnaire covered socio-demographic characteristics of the respondent's knowledge related to the vaccine, misconceptions related to the vaccine, perceived reliable sources, and acceptability of the vaccine. The COVID-19 vaccine acceptance rate was 76% in the study area. The vaccine acceptance rate was slightly lower among female participants (74%) in comparison to their male counterparts (78%). The Bivariate analysis showed a significant association of acceptance of the COVID-19 vaccine with the municipality, caste/ethnicity, and family type. Similarly, in the multivariate analysis, religion, caste/ethnicity, and disability statuses were found to be significantly associated with vaccine acceptance. Concluding that the COVID-19 pandemic cannot be curbed if people do not accept the vaccine. The findings of the study showed that a considerable proportion of the respondents did not accept the vaccine due to fear of the side effects and doubt about vaccine efficacy. Therefore there is a need to increase advocacy and awareness of the COVID-19 vaccine to increase people's trust in it.